Beilstein J. Org. Chem.2018,14, 3078–3087, doi:10.3762/bjoc.14.287
proceeds through a domino Knoevenagel/cyclization/Michael addition/oxidative cyclization reaction sequence.
Keywords: 2-aminochromene; domino reaction; imidazo[1,2-a]pyridine; 2-iminochromene; Michael addition; multicomponent reaction; oxidation; pyridineamination; Introduction
Domino reactions are well
reaction (Table 1, entry 10). The use of KMnO4 which is known as a classical oxidant for pyridineamination [46], gave desired chromenoimidazopyridine 5a with admissible 47% yield (Table 1, entry 11). The yield of 54% was achieved with Mn(OAc)3·2H2O (Table 1, entry 12), while increasing the reaction time
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Graphical Abstract
Figure 1:
Biologically relevant imidazo[1,2-a]pyridines and chromenes.